Still Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus

Still Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus


As states reopen from stay-at-home orders, many, including California, are now requiring people to wear face coverings in most public spaces to reduce the spread of COVID-19.


Both the Centers for Disease Control and Prevention (CDC) and the World Health Organization now recommend cloth masks for the general public, but earlier in the pandemic, both organizations recommended just the opposite. These shifting guidelines may have sowed confusion among the public about the utility of masks.


But health experts say the evidence is clear that masks can help prevent the spread of COVID-19 and that the more people wearing masks, the better.


We talked to UC San Francisco epidemiologist George Rutherford, MD, and infectious disease specialist Peter Chin-Hong, MD, about the CDC’s reversal on mask-wearing, the current science on how masks work, and what to consider when choosing a mask.


Why did the CDC change its guidance on wearing masks?


The original CDC guidance partly was based on what was thought to be low disease prevalence earlier in the pandemic, said Chin-Hong.


“So, of course, you’re preaching that the juice isn’t really worth the squeeze to have the whole population wear masks in the beginning – but that was really a reflection of not having enough testing, anyway,” he said. “We were getting a false sense of security.”


Rutherford was more blunt. The legitimate concern that the limited supply of surgical masks and N95 respirators should be saved for health care workers should not have prevented more nuanced messaging about the benefits of masking. “We should have told people to wear cloth masks right off the bat,” he said.


Another factor “is that culturally, the U.S. wasn’t really prepared to wear masks,” unlike some countries in Asia where the practice is more common, said Chin-Hong. Even now, some Americans are choosing to ignore CDC guidance and local mandates on masks, a hesitation that Chin-Hong says is “foolhardy.”


What may have finally convinced the CDC to change its guidance in favor of masks were rising disease prevalence and a clearer understanding that both pre-symptomatic and asymptomatic transmission are possible – even common. Studies have found that viral load peaks in the days before symptoms begin and that speaking is enough to expel virus-carrying droplets.


“I think the biggest thing with COVID now that shapes all of this guidance on masks is that we can’t tell who’s infected,” said Chin-Hong. “You can’t look in a crowd and say, oh, that person should wear mask. There’s a lot of asymptomatic infection, so everybody has to wear a mask.”


What evidence do we have that wearing a mask is effective in preventing COVID-19?


There are several strands of evidence supporting the efficacy of masks.


One category of evidence comes from laboratory studies of respiratory droplets and the ability of various masks to block them. An experiment using high-speed video found that hundreds of droplets ranging from 20 to 500 micrometers were generated when saying a simple phrase, but that nearly all these droplets were blocked when the mouth was covered by a damp washcloth. Another study of people who had influenza or the common cold found that wearing a surgical mask significantly reduced the amount of these respiratory viruses emitted in droplets and aerosols.


But the strongest evidence in favor of masks come from studies of real-world scenarios. “The most important thing are the epidemiologic data,” said Rutherford. Because it would be unethical to assign people to not wear a mask during a pandemic, the epidemiological evidence has come from so-called “experiments of nature.”


A recent study published in Health Affairs, for example, compared the COVID-19 growth rate before and after mask mandates in 15 states and the District of Columbia. It found that mask mandates led to a slowdown in daily COVID-19 growth rate, which became more apparent over time. The first five days after a mandate, the daily growth rate slowed by 0.9 percentage-points compared to the five days prior to the mandate; at three weeks, the daily growth rate had slowed by 2 percentage-points.


Another study looked at coronavirus deaths across 198 countries and found that those with cultural norms or government policies favoring mask-wearing had lower death rates.


Two compelling case reports also suggest that masks can prevent transmission in high-risk scenarios, said Chin-Hong and Rutherford. In one case, a man flew from China to Toronto and subsequently tested positive for COVID-19. He had a dry cough and wore a mask on the flight, and all 25 people closest to him on the flight tested negative for COVID-19. In another case, in late May, two hair stylists in Missouri had close contact with 140 clients while sick with COVID-19. Everyone wore a mask and none of the clients tested positive.


Do masks protect the people wearing them or the people around them?


“I think there’s enough evidence to say that the best benefit is for people who have COVID-19 to protect them from giving COVID-19 to other people, but you’re still going to get a benefit from wearing a mask if you don’t have COVID-19,” said Chin-Hong.


Masks may be more effective as a “source control” because they can prevent larger expelled droplets from evaporating into smaller droplets that can travel farther.


Another factor to remember, noted Rutherford, is that you could still catch the virus through the membranes in your eyes, a risk that masking does not eliminate.


How many people need to wear masks to reduce community transmission?


“What you want is 100 percent of people to wear masks, but you’ll settle for 80 percent,” said Rutherford. In one simulation, researchers predicted that 80 percent of the population wearing masks would do more to reduce COVID-19 spread than a strict lockdown.


The latest forecast from the Institute of Health Metrics and Evaluation suggests that 33,000 deaths could be avoided by October 1 if 95 percent of people wore masks in public.


Even if you live in a community where few people wear masks, you would still reduce your own chances of catching the virus by wearing one, said Chin-Hong and Rutherford.


Does the type of mask matter?


Studies have compared various mask materials, but for the general public, the most important consideration may be comfort. The best mask is one you can wear comfortably and consistently, said Chin-Hong. KN95 face mask is only necessary in medical situations such as intubation. Surgical masks are generally more protective than disposable mask, and some people find them lighter and more comfortable to wear.


The bottom line is that any mask that covers the nose and mouth will be of benefit.


“The concept is risk reduction rather than absolute prevention,” said Chin-Hong. “You don’t throw up your hands if you think a mask is not 100 percent effective. That’s silly. Nobody’s taking a cholesterol medicine because they’re going to prevent a heart attack 100 percent of the time, but you’re reducing your risk substantially.”


However, both Rutherford and Chin-Hong cautioned against KN95 masks with valves (commonly used in construction to prevent the inhalation of dust) because they do not protect those around you. These one-way valves close when the wearer breathes in, but open when the wearer breathes out, allowing unfiltered air and droplets to escape. Chin-Hong said that anyone wearing a valved mask would need to wear a surgical or cloth mask over it. "Alternatively, just wear a non-valved mask," he said.


San Francisco has specified that masks with valves do not comply with the city's face covering order.


If we’re practicing social distancing, do we still need to wear masks?


A mnemonic that Chin-Hong likes is the “Three W’s to ward off COVID-19:” wearing a mask, washing your hands, and watching your distance.


“But of the three, the most important thing is wearing a mask,” he said. Compared to wearing a mask, cleaning your iPhone or wiping down your groceries are “just distractors.” There’s little evidence that fomites (contaminated surfaces) are a major source of transmission, whereas there is a lot of evidence of transmission through inhaled droplets, said Chin-Hong.


“You should always wear masks and socially distance,” said Rutherford. “I would be hesitant to try to parse it apart. But, yes, I think mask wearing is more important.”