Tangential flow filtration devices are Easy to set up and use. You just need to simply connect the TFF device to a pump and pressure gauge(s) with tubing and a few fittings, add your sample to the reservoir, and begin filtration. It is easier to set up and much faster than dialysis. Higher concentrations can be achieved in less time than when using centrifugal devices or stirred cells. The device concentrates and diafilters a sample on the same system, saving time and avoiding product loss. It can be scaled up or scaled down. Materials of construction and cassette path length allow conditions established during pilot-scale trials to be applied to process scale applications.
Tangential flow filtration system is a rapid and efficient method for separation and purification of biomolecules. It can be applied to a wide range of biological fields such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology. TFF can be used to concentrate and desalt sample solutions ranging in volume from 10 mL to thousands of liters. It can be used to fractionate large from small biomolecules, harvest cell suspensions, and clarify fermentation broths and cell lysates.
Production tangential flow filtration system is a versatile and efficient solution for virtually any form of filtration, purification, and/or clarification at any phase of the bioproduction train. Tangential flow filtration systems are designed and built to the specific requirements of microfiltration, ultrafiltration, or nanofiltration applications. Typical TFF applications include fermentation cell culture clarification, diafiltration, protein purification/concentration, and blood fractionation processing.
Centrifugal filter devices are designed to fit inside centrifuge tubes that are used to filter out larger particles, such as cells or particulates, from a sample as it is centrifuged. Products may be available in several sizes, materials, etc.
Centrifugal ultrafiltration device is ideal for many small-scale laboratory operations. These products can be used to process samples ranging from 50 μL to 60 mL in volume. The first consideration in selecting the correct centrifugal device is the volume of starting material.
Ultrafiltration tube through the centrifugation to remove biological macromolecules which is significantly larger than filter pore size to improve the solute concentration of biological macromolecules, more than 90% recovery. Products are consisted of the tube cap, ultrafiltration intubation and tube body.
Depth filter is the variety of filters that use a porous filtration medium to retain particles throughout the medium, rather than just on the surface of the medium. These filters are commonly used when the fluid to be filtered contains a high load of particles because, relative to other types of filters, they can retain a large mass of particles before becoming clogged. Depth filtration typified by multiple porous layers with depth are used to capture the solid contaminants from the liquid phase. Due to the tortuous and channel-like nature of the filtration medium, the particles are retained throughout the medium within its structure, as opposed to on the surface. Depth filters pose the added advantage that they are able to attain a high quantity of particles without compromising the separation efficiency. Depth filters are commonly characterised by the sand filter and have the ability to be used with substantially higher filter rates than in other designs. It is these characteristics that have cemented the use and popularity of depth filters as an effective medium for separation. With ongoing advances in process technologies depth filter designs are continuously adapting and improving to meet the needs of industry.
Depth filtration capsule is used to remove a broad range of particles, such as dirt, grit, sand, organic solids and rust particles. Made of carefully selected materials such as polypropylene, cotton and glass fibre, the cartridges physically intercept particles and prevent them from ending up in the final filtered liquid.
Single-use depth filter is designed for bioprocess applications. It consists of a set of inlet and outlet single-use manifolds with vents and a flexible number of capsule filters placed between those manifolds. Each capsules is designed to fit in a holder that can be pivoted between horizontal and vertical positions to allow for convenient loading and unloading at an operator's waist height. A cam locking mechanism provides capsule-to-capsule connection to ensure a robust and integral seal between filter capsules. The capsule is designed with a lenticular-style filter inside, similar to a conventional filter described earlier.
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